DNA Health® tests for genetic variations that are known to have a significant effect on health and susceptibility to chronic diseases such as osteoporosis, cancer, neural tube defects, cardiovascular disease, and diabetes, amongst others.
Nutrigenomics research has shown that individualized diet and lifestyle choices do have a signifi cant eff ect on the expression of these genes – but this also depends on early detection and appropriate intervention.
DNA Health Test
DNA Health® reports on genes involved in the following areas:
- Cholesterol metabolism and responsiveness to diet
- Food responsiveness - sensitivities to lactose, caffeine, gluten and salt intake
- Bone Health
- Methylation
- Inflammation
- Oxidative Stress
- Insulin Resistance
The DNA Health test is suitable for any individual who wants optimise their health by learning how they can support their genes through nutrition and lifestyle. The DNA Health test is designed to optimise well-being and health by personalising lifestyle and diet choices and, where necessary, using supplements tailored to offset any particular nutritional deficit based on specific gene variants.
- Highlights specific metabolic pathways that may require extra support
- Provides recommendations that involve optimisation of quantities of certain nutrients, vitamins and minerals
- Suggests whether an individual is better able to reduce their cholesterol levels through diet, as opposed to through medication
- Provides an indication of the degree of susceptibility to the harmful effects of carcinogens ingested in the diet
Analytes measured:
Lipid Metabolism
LPL: Removes lipids from the circulation by hydrolysing triglycerides into free fatty acids.
CETP: Plays a key role in the metabolism of HDL and mediates the exchange of lipids between lipoproteins.
APOC3: Plays an important role in cholesterol metabolism.
APOE: Is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Affects antioxidant requirement.
B Vitamins/Methylation
MTHFR: Directs folate from the diet either to DNA synthesis or homocysteine re-methylation.
MTR: Catalyses the re-methylation of homocysteine to methionine.
COMT: Catalyses the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
MTRR: Catalyses methylcobalamin, which is essential for maintaining adequate intracellular pools of methionine. It is also responsible for maintaining homocysteine concentrations at non-toxic levels.
CBS: Catalyses the conversion of homocysteine to cystathionine and is directly involved in the removal of homocysteine from the methionine cycle.
Detoxification
CYP1A1: The cytochrome P450 enzyme converts environmental pro-carcinogens to reactive intermediates, which are carcinogenic.
GSTM1: Influences Phase II detoxification. It is responsible for the removal of xenobiotics, carcinogens, and products of oxidative stress.
GSTP1: Influences the metabolism of many carcinogenic compounds.
GSTT1: A member of a super family of proteins that catalyses the conjugation of reduced glutathione.
NQO1: Quinone Reductase is primarily involved in the detoxification of potentially mutagenic and carcinogenic quinones derived from tobacco smoke, diet and oestrogen metabolism.
Inflammation
IL-6: Plays a crucial role in inflammation by regulating the expression of C reactive protein (CRP).
TNF-A: TNFa is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole body glucose homeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.
Food Responsiveness and Sensitivity
MCM6: Associated with adult hypolactasia.
FADS1: Influences blood fat concentrations by affecting desaturase enzyme efficiency.
CYP1A2: This detoxification enzyme influences the ability to metabolise caffeine.
ACE & AGT: Part of the renin-angiotensin system and response to salt.
HLA DQ2/DQ8: Major genetic predisposition for coeliac diseaseVitamin Metabolism
BC01: Catalysing carotenoids to retinal (vitamin A)
CYP2R1: Conversion of vitamin D to 25(OH)D
FUT2: Vitamin B12 absorption and transport
GSTT1: Contributing to glutathione-ascorbic acid (vitamin C) antioxidant cycle
Iron Overload
HFE: Regulates iron absorption by regulating the interaction of the transferring receptor with transferrin. Hereditary haemochromatosis results from defects in the HFE gene.
Oxidative Stress
eNOS: Influences vascular tone and peripheral vascular resistance. It also has vaso-protective effects by suppressing platelet aggregation, leukocyte adhesion and smooth muscle cell proliferation.
MnSOD/SOD2: Has vital anti-oxidant activity within the cell, especially within the mitochondria. It destroys the radicals that are normally produced within cells.
Bone Health
VDR: Has a profound influence on bone density.
COL1A1: Influences the ratio of collagen-alpha chains produced by bone cells, affecting bone mineralisation of bone and bone strength.
Insulin Sensitivity
PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism.
TCF7L2: Influences blood glucose homeostasis – both insulin secretion and resistance.
FTO: Influences susceptibility to obesity and risk for type 2 diabetes.
SLC2A2: Facilitates glucose induced insulin secretion and is involved in food intake and regulation.Sample required: Bloodspot
Average processing time: 18-21 days
Shipping: Test will be shipped to your address and then will be collected from your address and shipped directly to the laboratory
Privacy policy: The DNA and the original sample material are destroyed after 3 months, so that there are no names or other identifiers on the samples. The samples are analysed only for the SNPs that are included in the tests at DNALife, and no other research or analyses are performed without a separate permission from the patient. We do not give or sell the results to any third parties.